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1- Abratt R.P. et al., " Weekly Gemcitabine With Monthly Cisplatin : Effective Chemotherapy for Advanced Non-Small-Cell Lung Cancer ", J. Clin. Oncol., 1997, 2, pp. 744-749.

2- Alberts D.S. et al., " Improved therapeutic index of Carboplatin plus Cyclophosphamide : final report by the southwest oncology group of a phase III randomized trial in stages III and IV ovarian cancer ", J. Clin. Oncol., 1992, 10, pp. 706-717.

3- André T et al., " Bi-monthly CPT11 with leucovorin and 5-fluorouracil in pretreated metastatic colorectal cancer (FOLFIRI), Proc. Am. Soc. Clin. Oncol., 1998, 17, p. 1051.

4- Bagley C.M. Jr et al., " Advanced lymphosarcoma : intensive cyclical combination chemotherapy with cyclophosphamide, vincristine and prednisone ", Ann. Intern. Med., 1972, 76, pp. 227-234.

5- Bartelink H et al., " Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer : results of a phase III randomised trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups ", J. Clin. Oncol., 1997, 15, pp. 2040-2049.

6- Bolla M. et al., " Données actuelles de l'association radiothérapie-hormonothérapie dans les cancers de la prostate localisés et localement évolués ", Cancer/Radiother., 1998, 2, pp. 1-2.

7- Bonneterre J., " FEC 50 versus FEC 100, Résultats de l'étude randomisée FEC 50 versus FEC 100 comme chimiothérapie adjuvante chez les patientes ayant un cancer du sein de mauvais pronostic N+ ", Proc. Am. Soc. Clin. Oncol., 1998, 17, p. 124.

8- Bourhis J. et al., " Meta-Analysis of Chemotherapy in Head and Neck Cancer (MACH-NC) : loco-regional treatment vs same treatment + chemotherapy (CT) ", Proc. Am. Soc. Clin. Oncol., 1998, 17, p. 386.

9- Burrhis HA et al. " Single-agent docetaxel (Taxotere) in randomized phase III trials ", Semin. Oncol., 1999, 26, pp. 1-6.

10- Bretti S. et al., " Multicenter Phase II trial of intermediate dose cisplatin and vinorelbine in inoperable non-small cell lung cancer patients ", Lung cancer, 1996, 14, pp. 353-360.

1- Bruno S. et al., " Phase II trial of weekly I.V. Vinorelbine as a single agent in first-line Advanced Breast Cancer chemotherapy ", Am. J. Clin. Oncol., 1995, 18, pp. 392-396.

12- Calais G. et al., " Randomized study comparing radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma (ARCORO). Preliminary results of the 94.01 study from the french group of radiation oncology for head and neck cancer (GORTEC) ", Proc. of Am. Soc. Clin. Oncol., 1998, 17, p. 385.

13- Calero et al., " Clinical evaluation of epirubicin in endometrial adenocarcinoma and uterine cervix carcinoma ", Proc. of Am. Soc. Clin. Oncol., 1989, 8, p. 156.

14- Cancer, Principles and Practice of Oncology, De Vita Ed., 1995, 4ème Edition, pp. 1006-1022.

15- Chapman P.-B. et al., " Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic malanoma ", J. Clin. Oncol., 1999, 17, pp. 2745-2751.

16- Chavaudra, " Dernières recommandations de l'ICRU pour la prescription, l'enregistrement et le compte-rendu de la radiothérapie externe ", Cancer/Radiother., 1998, 2, pp. 607-614.

17- Creemers G.J. et al., " Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer : results of a large european phase II study ", J. Clin. Oncol., 1996, 14, pp. 3056-3061.

18- De Gramont A. et al., " Chimiothérapie 2ème ligne des cancers colorectaux métastatiques, Oxaliplatine : synergie avec le 5-FU ", Eur. J. Cancer, 1995, 31A, p. 716.

19- De Gramont A. et al., " Randomised trial comparing monthly low-dose Leucovorin and Fluorouracil bolus with bimonthly high-dose Leucovorin and Fluorouracil bolus plus continuous infusion for advanced colorectal cancer : a french intergroup study ", J. Clin. Oncol., 1997, 15, pp. 808-815

20- DeOlivera CF et al., " Chemotherapy of advanced endometrial carcinoma with cyclophosphamide, adriamycin and cisplatin (CAP) : First meeting of the International Gynecologic Cancer Society ", abst. Amsterdam, 1987, 10.

21- Depierre and al., " An ongoing randomized study of neoadjuvant chemotherapy in resectable non-small cell lung cancer ", Semin. Oncol., 1994, 21, pp. 16-19.

22- DeVita VT et al., " Combination chemotherapy in the treatment of advanced Hodgkin's disease ", Ann. of Intern. Med., 1970, 73, pp. 881-895.

23- Douillard J.Y. et al., " Tomudex (Raltitrexed) plus Oxaliplatin as First-Line Chemotherapy in Metastatic Colorectal Cancer (MCRC) Patients : A promising combination, Proc. Am. Soc. Clin. Oncol., 1999, 18, p. 257.

24- Douillard J.Y. et al., " Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer : a multicentre randomised trial ", Lancet., 2000, 355, pp. 1041-1047.

25- Du Bois A. et al., " Cisplatin/paclitaxel versus carboplatin plus paclitaxel as first-line chemotherapy in ovarian cancer : interim analysis of AGO Study Group trial ", Proc. Am. Soc. Clin. Oncol., 1997, 16, p. 357.

26- Elias A. et al., " Mesna, doxorubicine, ifosfamide, dacarbazine (Maid) regimen for adults with advanced sarcoma ", Sem. Oncol., 1990, 17, pp. 41-47.

27- " Epidermoid anal cancer : results from the UKCCCR randomised trial of radiotherapy alone versus radiotherapy, 5 fluorouracil and mitomycin ", UKCCCR Anal Cancer Trial Working Party, Lancet., 1996, 348, pp. 1049-1054.

28- Eschwege F. et al., " Randomized mutticentric international phase III trial of neoadjuvant chemotherapy (NACI) with Bleomycin (B), Epirubicin (E), Cisplatin (C), followed by radiotherapy versus radiotherapy alone in undifferentiated carcinoma of nasopharyngeal type (UCNT) : preliminary results", Int. J. Radiat. Oncol. Biol. Phys., 1995, 32, p. 192.

29- French Epirubicin Study Group, " A prospective randomized phase III trial comparing combination chemotherapy with Cyclophosphamide, Fluorouracil and either Doxorubicin or Epirubicin ", J. Clin. Oncol., 1988, 6, pp. 679-688.

30- Frewin R. et al., " Combination therapy with fludarabine and cyclophosphamide as salvage treatment in lymphoproliferative disoreders ", Br. J. Haematol., 1999, 104, pp. 612-613.

31- Frustaci S. et al., " Epirubicin and ifosfamide in advanced soft tissue sarcomas ", Ann. Oncol., 1993, 4, p. 669.

32- Giachetti et al., " Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery ", Ann. of Oncol., 1999, 10, pp. 663-669.

33- Gottlieb Ja. Et al., " An effective new four drug combination regimen (CY-VA-DIC) for metastatic sarcomas ", Proc. Am. Soc. Clin. Oncol., 1974, 15, p. 162.

34- Herskovic A. et al., " Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the sophagus ", N. Engl. J. Med., 1992, 326, pp. 1593-1598.

35- Hill M. et al., " ECF (Epirubicin, Cisplatin and Protacted venous infusion (PVI) 5-FU) is a highly active, low toxicity regimen for sophagogastric cancer which can downstage tumours prior to curative surgery ", Proc. Am. Soc. Clin. Oncol., 1995, 14, 197.

36- Holmes F.A. et al., " Mitoxantrone, cyclophosphamide, and fluoro-uracil in metastatic breast cancer unresponsive to hormonal therapy ", Cancer., 1987, 59, pp. 1992-1999.

37- Hoerni B. et al., " New combination of epirubicine, bleomyci, vinblastine and prednisolone (EBVP II) before radiotherapy in localized stages of Hodgkin's disease. Phase II trial in 50 patients ", Bull. Cancer., 1988, 75, pp. 789-794.

38- Howard A. et al., " Improvements in Survival and Clinical Benefit With Gemcitabine as First-Line Therapy for Patients With Advanced Pancreas Cancer : A Randomized Trial ", J. Clin. Oncol., 1997, 15, pp. 2403-2413.

39- Impact investigators, " Efficacy of adjuvant fluorouracil and folinic acid in colon cancer ",, Lancet., 1995, 345, pp. 939-944.

40- Jacob J.H. et al., " Definitive concurrent chemo-radiation therapy in squamous cell carcinoma of the oesophagus : preliminary results of a French randomized trial comparing standard vs split course irradiation ", Proc. Am. Soc. Clin. Oncol., 1999, 18, p. 270.

41- Kaye SB et al., " Intensive induction-sequential chemotherapy with BOP/VIP-B compared with treatment with BEP/EP for poor-prognosis metastatic nonseminomatous germ cell tumor: A randomized Medical Research Council/European Organization for Research and Treatment of Cancer ", J. Clin. Oncol., 1998, 16, pp. 692-701.

42- Kemeny N. et al., " Randomized study of hepatic arterial infusion and systemic chemotherapy versus systemic chemotherapy alone as adjuvant therapy after resection of hepatic metastases from colorectal cancer ", Proc. of Am. Soc. Clin. Oncol., 1999, 18, p. 263.

43- Keys et al., " Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulkystage IB cervical carcinoma ", N. Engl. J. Med., 1999, 340, pp. 1154-1161.

44- Kish J.A. et al., " Carboplatin and 5 FU infusion as an effective out patient induction chemotherapy in patients with locally advanced head and neck cancer ", Proc. Am. Soc. Clin. Oncol., 1989, 8, p. 174.

45- Klaassen A. et al., " Paclitaxel in combination with weekly 24-hour infusional 5-fluorouracil plus leucovorin in the second-line treatment of metastatic breast cancer : Results of a phase II study ", Ann. Oncol., 1998, 9, pp. 45-50.

46- Klimo P. et al., " MOPP/ABV Hybrid Programm : Combination Chemotherapy Based on Early Introduction of Seven Effective Drugs for Advanced Hodgkin's Disease ", J. Clin. Oncol., 1985, 3, pp. 1174-1182.

47- Kosmidis P. A. et al., " Cisplatin/Etoposide versus Carboplatin/Etoposide chemotherapy and irradiation in Small Cell Lung Cancer : a randomized phase III study ", Sem. Oncol., 1994, 21, pp. 23-30.

48- Lauer Rc. Et al., " Cisplatin and ifosfamide and either VP-16 or vinblastine (VIP) as third line therapy for metastatic testicular cancer ", Proc. Am. Soc. Clin. Oncol., 1987, 8, p. 99.

49- Lhrer P.J. et al., " A randomised comparison of Cisplatine alone or in combination with Methotrexate, Vinblastine, an Doxorubicin in patients with metastatic urothelial carcinoma : a cooperative group study ", J. Clin. Oncol., 1992, 10, pp. 1066-1073.

50- Malhaire JP et al., " Fotemustine (Muphoran (R) in 22 patients with relapses of high-grade cerebral gliomas ", Bull. Cancer., 1999, 86, pp. 289-294.

51- Mc Kelvey E.M. et al., " Hydroxydaunomycin (adriamycin) combination chemotherapy in malignant lymphoma ", Cancer., 1976, 38, pp. 1484-1493.

52- Miller et al., " Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate and high-grade non-Hodgkin's lymphoma ", N. Engl. J. Med. 1998, 339, pp. 21-26.

53- Mineur P. et al., VAD or VMBCP in multiple myeloma refractory to or relapsing after cyclophosphamide-prednisone therapy (protocol MY 85), Br. J. Haematol., 1998, 103, pp. 512-517.

54- Moertel CG et al., " Combination chemotherapy trials in metastatic carcinoid and malignant carcinoid syndrome ", Cancer Clin. Trials., 1979, 2, p. 327.

55- Munzenrider J.E. et al., " Use of body scanner in radiotherapy treatment planning ", Cancer., 1997, 40, pp. 170-179.

56- Namer M. et al., " Is the combination FAC/FEC always the best regimen in advanced breast cancer (ABC) ? Utility of mitoxantrone (M) and Vinorelbine (V) association as an alternative in some situations. Results from a phase III prospective randomized trial ", Breast Cancer Research and Treatment, 1997, 46, p. 94.

57- Nordic Gastrointestinal Tumor Adjuvant Tharapy Group, " Expectancy or primary chemotherapy in patients with advanced asymptomatic colorectal cancer : a randomized trial ", J. Clin. Oncol., 1992, 10, pp. 904-911.

58- O'Connel M. et al., " Improving adjuvant therapy for rectal cancer by combining protacted-infusion fluorouracil with radiationtherapy after curative surgery ", N. Engl. J. Med., 1994, 331, pp. 502-507.

59- Peters WA et al., " Cisplatin, 5-fluorouracil plus radiation therapy are superior to radiation therapy as adjunctive therapy in high-risk, early-stage carcinoma of the cervix after radical hysterectomy and pelvic lymphadenectomy : report of a phase III inter-group study. 30th annual meeting of the Society of Gynecologic Oncologists, San Francisco, CA, USA, March 20-24, 1999.

60- Prados MD et al., " Procarbazine, Lomustine, and Vincristine (PCV) Chemotherapy for Anaplastic Astrocytoma : A Retrospective Review of Radiation Therapy Oncology Group Protocols Comparing Survival With Carmustine or PCV Adjuvant Chemotherapy ", J. Clin. Oncol., 1999, 17, pp. 3389-3395

61- Pyrhönen S. et al., " Prospective randomized trial of Interferon Alfa-2a plus Vinblastine versus Vinblastine alone in patients with advanced renal cell cancer ", J. Clin. Oncol., 1999, 17, pp. 2859-2867.

62- Raymond et al., " Chimiothérapie de 2ème ligne des cancers colorectaux métastatiques, Oxaliplatine : synergie avec le 5-FU ", Proc. Am. Ass. Clin. Res., 1996, 37, p. 291.

63- Rose PG et al., " Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer ", N. Engl. J. Med., 1999, 340, pp. 1154-53.

64- Salmon SE. et al., " Alternating combination chemotherapy improves survival in multiple myeloma : a Southwest Oncology Group study ", J. Clin. Oncol. 1983, 1, p. 453.

65- Shipp M.A., " Identification of major prognostic subgroups of patients with large cell lymphoma treated with m-BACOD ", Ann. Intern. Med., 1986, 104, pp. 757-765.

66- Swenerton et al., " Cisplatin-cyclophosphamide versus carboplatin-cyclophosphamide in advanced ovarian cancer : a randomized phase III study of the National Cancer Iistitute of Canada Clinical Trials Group ", J. Clin Oncol., 1992, 10, pp. 718-726.

67- Tannock I. F. et al., " Chemotherapy With Mitoxantrone Plus Prednisone or Prednisone Alone for Symptomatic Hormone-Resistant Prostate Cancer : A Canadian Randomized Tial With Palliative End Points ", J. Clin. Oncol., 1996, 14, pp. 1756-1764.

68- Theriault R. L., " Le pamidromate réduit la morbidité osseuse chez les femmes présentant un cancer du sein à un stade avancé et des métastases ostéolytiques : résultats d'un essai randomisé contrôlé contre placebo ", J. Clin. Oncol., 1999, 17, pp. 846-854.

69- Tourani J.-M. et al., " Traitement ambulatoire par interleukine 2 administrée par vois sous-cutanée chez des patients porteurs d'un cancer du rein métastatique. Résultats à 3 ans du programme SCAPPI ", Bull. Cancer., 1997, 84, pp. 351-356.

70- Vaishampayan U. et al., " Phase II Evaluation of Carboplatin, Paclitaxel and Gemcitabine in Advanced Urothelial Carcinoma ", Proc. Am. Soc. Clin. Oncol., 1999, 18 , p. 333.

71- Vogel C. et al., " Vinorelbine as first-line chemotherapy for advanced breast cancer in women 60 years of age or older ", Ann. Oncol., 1999, 10, pp. 397-402.

72- Weaver A. et al., " Cis-Platinum and 5-Fluorouracil as induction therapy for advanced head and neck cancer ", Am. Surg. 1982, 144, pp. 445-448.

73- Wilke et al., " Preliminary analysis of a randomized phase III trial of FAMTX versus ELF versus Cisplatin/FU in advanced gastric cancer (GC). A trial of the EORTC Gastrointestinal tract cancer cooperative group and the AIO (Arbeitsge-meinschaft internistische onkologie) ", Proc. Am. Soc. Clin. Oncol., 1995, 14, p. 206.

74- Williams S.D., " Treatment of dissimenated germ cell tumors with cisplatin, bleomycin, and either vinblastin or etoposide ", N. Engl. J. Med., 1987, 316, pp. 1435-1440.

75- Zalcberg JR. Et al., " ZD1694 : A novel thymidylate synthetase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer ", J. Clin. Oncol., 1996, 14, pp. 716-721.

76- Zamboglou N. et al., " Carboplatin and radiotherapy in the treatment of head and neck cancer : six year's experience ", Sem. Oncol. 1994, 21, pp. 45-53.